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DoD Peer Reviewed Alzheimer’s, Accelerating Diagnostics for Traumatic Brain Injury Research Award
The intent of the FY20 PRARP ADTBI is to support high-impact, human-based development of robust diagnostic and/or prognostic biomarkers for chronic TBI as they pertain to AD/ADRD.
It is anticipated that the proposed work will qualify clinically useful biomarkers for rapid transfer to clinical
practice.
The FY20 PRARP ADTBI mechanism defines biomarker qualification as the evidentiary process of linking a biomarker with biological processes and clinical end points.
Applications may consider elements of biomarker validation as part of the application.
Biomarker validation is defined as assessing the biomarker’s measurement performance characteristics in terms of reproducibility, accuracy, precision, and limits of sensitivity.
Applications that detail biomarker validation work should demonstrate how this research is relevant to overall biomarker qualification.
As part of the application, the proposed biomarkers should demonstrate their potential for improved specificity and sensitivity with respect to diagnosis and/or prognosis of chronic TBI as it pertains to AD/ADRD as the study endpoint.
The FY20 PRARP ADTBI does not support basic discovery of biomarkers.
As such, animal research is prohibited.
The proposed biomarker for investigation must correlate with clinical endpoints to include cognition and/or behavior relevant to both TBI and AD/ADRD research.
As part of the application, the PI should demonstrate that the study team has experience in both TBI and AD/ADRD research.
The FY20 PRARP ADTBI encourages applications to consider fluid-based, imaging-based, retinal or wearable devices as potential diagnostics.
Demonstration of access to an already existing cohort or provision of a plan that demonstrates expedited participant accrual is required.
In addition, suitability of the existing cohort or participant population must be detailed.
Applications must therefore describe how the anticipated outcome(s) can be attributable to the results of the proposed research (short-term gains), as well as consider the long-term scientific gains from the proposed research project.
FY20 PRARP ADTBI applications must be Impact-based.
It is anticipated that the proposed work will qualify clinically useful biomarkers for rapid transfer to clinical
practice.
The FY20 PRARP ADTBI mechanism defines biomarker qualification as the evidentiary process of linking a biomarker with biological processes and clinical end points.
Applications may consider elements of biomarker validation as part of the application.
Biomarker validation is defined as assessing the biomarker’s measurement performance characteristics in terms of reproducibility, accuracy, precision, and limits of sensitivity.
Applications that detail biomarker validation work should demonstrate how this research is relevant to overall biomarker qualification.
As part of the application, the proposed biomarkers should demonstrate their potential for improved specificity and sensitivity with respect to diagnosis and/or prognosis of chronic TBI as it pertains to AD/ADRD as the study endpoint.
The FY20 PRARP ADTBI does not support basic discovery of biomarkers.
As such, animal research is prohibited.
The proposed biomarker for investigation must correlate with clinical endpoints to include cognition and/or behavior relevant to both TBI and AD/ADRD research.
As part of the application, the PI should demonstrate that the study team has experience in both TBI and AD/ADRD research.
The FY20 PRARP ADTBI encourages applications to consider fluid-based, imaging-based, retinal or wearable devices as potential diagnostics.
Demonstration of access to an already existing cohort or provision of a plan that demonstrates expedited participant accrual is required.
In addition, suitability of the existing cohort or participant population must be detailed.
Applications must therefore describe how the anticipated outcome(s) can be attributable to the results of the proposed research (short-term gains), as well as consider the long-term scientific gains from the proposed research project.
FY20 PRARP ADTBI applications must be Impact-based.
Agency: Department of Defense
Office: Dept. of the Army -- USAMRAA
Estimated Funding: $15,000,000
Office: Dept. of the Army -- USAMRAA
Estimated Funding: $15,000,000
Obtain Full Opportunity Text:
THERE IS NO FULL ANNOUNCEMENT ASSOCIATED WITH THIS OPPORTUNITY
Additional Information of Eligibility:
Land-Grant Institutions, Colleges and universities having significant minority enrollments, other colleges and universities, and Institutes or research foundations maintained by an eligible college or university.
Institutions that have not previously applied are especially encouraged to do so.
Applicants must be institutions that confer a bachelor’s or D.V.M.
degree in at least one of the disciplines in the FANH sciences.
Awards are made to eligible colleges and universities.
Individuals are not eligible to apply for these grants
Full Opportunity Web Address:
HTTP://WWW.GRANTS.GOV
Contact:
Agency Email Description:
CDMRP Help Desk
Agency Email:
Date Posted:
2020-05-19
Application Due Date:
Archive Date:
2020-08-20
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